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Figure 1 ALS is a fatal neurodegenerative disease characterized by progressive degeneration of both the upper and lower motor neurons, which display cytoplasmic inclusions (Rowland and Shneider, 2001

The FDA has consistently made the widest use of the FRPs compared with other regulators and has achieved the shortest time to approval amongst leading NRAs

Poddar K, Kolge S, Bezman L, et al

(2020) 36:e3213

In summary, the crosstalk between autophagy and ferroptosis is governed by a complex, context-dependent network encompassing three core modes: i) Negative regulation, primarily through mTOR signaling and mitophagy, to inhibit ferroptosis