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Moreover glutaminolysis-mediated mTORC1 activation required prolyl hydroxylase (PHD) enzymatic activity in a HIF -independent manner [89]

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Kurtoglu YE, Navath RS, Wang B, Kannan S, Romero R, Kannan RM: Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery

All explants were independently assessed with an expert liver histopathologist to identify key histological features and correlate with clinical presentation

Univariate and multivariate analyses (Table 2) revealed that the serum level of pgRNA before HCC treatment ( p =0.001, HR [4.122, 1.7659.629]), maximum tumor diameter ( p =0.037, HR [1.095, 1.0061.192]), and total bilirubin ( p =0.024, HR [1.019, 1.0021.035]) were independent risk factors for recurrence

(Table 1) The patient displayed a high-anion gap metabolic acidosis (HAGMA): serum anion gap (AG), corrected for hypoalbuminemia equalled 25.3, c AG = AG + 2.5 (4-albumine in g/dL)