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Thirty-two male mice were started on a 60% high-fat diet of 5.24 kcal/g at three weeks of age for 19 weeks, followed by a 45% HFD of 4.73 kcal/g for six additional weeks

GERD patients frequently present with pressures well below this threshold, sometimes dropping to levels inadequate for preventing reflux even during normal activities

Volume of distribution calculations from pharmacokinetic studies indicate extensive tissue distribution beyond the vascular compartment

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it invalidates the entire premise of your research

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