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Hippo pathway contains a series of phosphorylation cascades in which the mammalian sterile 20-like kinase 1 and 2 (MST1/2) bind the salvador homolog 1 (SAV1) and subsequently activate the large tumor suppressor 1 and 2 (LATS1/2) by phosphorylation, collectively with MOB kinase activator 1 A and 1B (MOB1A/B) to phosphorylate YAP/TAZ, thus restricting the activities of transcriptional coactivators YAP and TAZ [87]