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Such Gln27 mutations, along with Arg16 mutations in adults, can result in an unfavourable cardiovascular profile (7981)

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As a Twist1 target, the transmembrane protein LRRC15 exhibited expression patterns closely correlated with TWIST1

While these pathways have been extensively elucidated in cancer models, emerging evidence suggests that similar ROS-driven senescenceinflammation feedback loops may play a pathogenic role in chronic metabolic diseases such as T2DM, thereby amplifying tissue dysfunction and insulin resistance ( In recent years, microRNAs (miRNAs) have garnered significant attention for their regulatory roles in mitochondrial homeostasis and ROS scavenging, emerging as critical molecular bridges between mitochondrial dysfunction and insulin resistance

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