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Other components of the DNA damage and BER machinery have been identified as specific readers of 5fC or 5caC, including p53, TDG, PARP, GADD45 and NEIL1/2 (Spruijt et al., 2013), and depletion studies of these factors in cells have shown that their activity is required to prevent DNA hypermethylation (Li et al., 2015

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Ann Neurol 48:297303 Terwel D, Bothmer J, Wolf E, Meng F, Jolles J (1998) Affected enzyme activities in Alzheimers disease are sensitive to antemortem hypoxia