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In vitro , the Abeta-Cu 2+ complex, in the presence of a reducing agent, reduces oxygen to produce H 2 O 2 , and this involves recycling copper from Cu 2+ to Cu 1+ and back to Cu 2+ along with the oxidation of the reducing agent (Jiang et al., 2010)

Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis