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Glossary CNS Central nervous system SCI Spinal cord injury TBI Traumatic brain injury IS Ischemic stroke CIRI Cerebral ischemia-reperfusion injury SAH Subarachnoid hemorrhage ICH Intracerebral hemorrhage NDDs Neurodegenerative diseases AD Alzheimers disease PD Parkinsons disease HD Huntingtons disease ROS Reactive oxygen species L-OOHs Lipid hydroperoxides Fe 2+ Ferrous iron LOX Lipoxygenase ACSL4 Acyl-CoA synthetase long-chain family member 4 GPX4 Glutathione peroxidase 4 Nrf2 Nuclear factor E2-related factor 2 ESCRT-III Endosomal sorting complexes required for transport III PUFAs Polyunsaturated fatty acidphospholipids PLs Phospholipids SFAs Saturated fatty acids MUFAs Monounsaturated fatty acids PUFA-PLs Polyunsaturated fatty acid-phospholipids AA Arachidonic acid AdA Adrenic acid PEs Phosphatidylethanolamines LPCAT3 Lysophosphatidylcholine acyltransferase 3 TZDs Thiazolidinediones TRO Troglitazone PIO Pioglitazone ROSI Rosiglitazone OH Hydroxyl radicals LO Lipid alkoxyl radicals L Lipid radicals LOO Lipid peroxyl radicals H 2 O 2 Hydrogen peroxide OH Hydroxide ions COXs Cyclooxygenases LB1 LOXBlock-1 4-HNE 4-hydroxy-2-nonenal MDA Malondialdehyde Hb Hemoglobin TF Transferrin TfR Transferrin receptor FT Ferritin FPN Ferroportin DMT1 Divalent metal transporter 1 LIP Labile iron pool RNAi RNA interference FTH1 Ferritin Heavy Chain 1 FTL Ferritin Light Chain NCOA4 Nuclear receptor coactivator 4 UPS Ubiquitin-proteasome system ATM Ataxia-telangiectasia-mutated PROM2 Prominin 2 MVBs Multivesicular bodies System Xc-/GSH/GPX4 axis Cystine/glutamate antiporter system-glutathione-glutathione peroxidase 4 axis FSP1/CoQ10/NADPH axis Ferroptosis suppressor protein 1-coenzyme Q10-nicotinamide adenine dinucleotide phosphate axis GCH1/BH4/DHFR axis GTP cyclohydrolase 1-tetrahydrobiopterin-dihydrofolate reductase axis SLC7A11 Light chain subunit solute carrier family 7 member 11 SLC3A2 Heavy chain subunit solute carrier family 3 member 2 GSH Glutathione TXNRD1 Thioredoxin reductase 1 GCL Glutamate-cysteine ligase GSS Glutathione synthase GSR Glutathione-S reductase ATF3 Activating transcription factor 3 ATF4 Activating transcription factor 4 mTOR Mammalian target of rapamycin mTORC1 MTOR complex 1 Keap1 Kelch-like ECH-associated protein 1 Cul3 Cullin 3 Rbx1 RING-box protein 1 sMAF Small Maf proteins ARE Antioxidant response elements PPP Pentose phosphate pathway G6PD Glucose-6-phosphate dehydrogenase HO-1 Heme Oxygenase-1 BBB Blood-brain barrier MCAO Middle cerebral artery occlusion HIF-1 Hypoxia-inducible factor-1 LncRNA Long non-coding RNA NF-B Nuclear factor kappa-light-chain-enhancer of activated B cells cPLA2 Cytosolic phospholipase A2 NMDA N-methyl-D-aspartate pMCAO Permanent middle cerebral artery occlusion circRNAs Circular RNAs OGD/R Oxygen-glucose deprivation/reperfusion MCAO/R Middle cerebral artery occlusion/reperfusion NAC N-acetylcysteine tMCAO Transient middle cerebral artery occlusion EBI Early brain injury DBI Delayed brain injury ATG5 Autophagy-related gene 5 CSF Cerebrospinal fluid SIRT1 Epigenetic regulator Sirtuin 1 CCI Controlled cortical injury EAAT1 Excitatory amino acid carrier type 1 A Amyloid-beta NFTs Neurofibrillary tangles SNpc Substantia nigra pars compacta SN Substantia nigra DA Dopaminergic Htt Huntingtin mHtt Mutant Huntingtin MRI Magnetic resonance imaging QSM Quantitative susceptibility mapping 3-NP Hippocampus of 3-nitropropionic acid DFO Deferoxamine DFP Deferiprone DFX Deferasirox AKI Acute kidney injury CPX Ciclopirox NSCLC Non-small cell lung cancer 2,2-BP 2,2-Bipyridyl 1,10-PT 1,10-Phenanthroline RTAs Radical-trapping antioxidants GSSH Glutathione hydropersulfide Se Selenium -TOH -Tocopherol VK Vitamin K VK1 Vitamin K1 RSSH Hydropersulfide RSSH/TSP Hydropersulfides/trans-sulfuration Fer-1 Ferrostatin-1 Lip-1 Liproxstatin-1 Lip-2 Liproxstatin-2 PTZs Phenothiazines PNXs Phenoxazines TEMPO Tetramethylpiperidine-N-oxyl BHT Butylated Hydroxytoluene BHA Butylated Hydroxyanisole RPE Retinal pigment epithelial D-PUFAs Deuterated PUFAs BXM Bardoxolone methyl FINs Class I ferroptosis inducers PUFA-PEs Polyunsaturated fatty acidphosphatidylethanolamines PKC Protein kinase C DPP4 Dipeptidyl-peptidase-4 SAEs Serious adverse events MDS-UPDRS Movement Disorder Society-Unified Parkinsons Disease Rating Scale ADL Activities of daily living DAT Enhanced dopamine transporter CMRglu Cerebral metabolic rate of glucose ADAS-Cog Alzheimers Disease Assessment Scale-Cognitive Subscale TIA Transient ischemic attack BC Baicalin BL Baicalein PCC-ABI Preoptic cistern autologous blood injection tBCCAO Transient bilateral common carotid artery occlusion PTGS2 Prostaglandin-endoperoxide synthase 2 FeCl 3 Ferric chloride FAC Ferric ammonium citrate PTE Post-traumatic epilepsy FTMT Mitochondrial ferritin CHY Chrysin HIF-1 Hypoxia-inducible factor 1 VTX Vitexin GAL Galangin BCCAO/R Bilateral common carotid artery occlusion/reperfusion MWM Morris water maze 6-OHDA 6-hydroxydopamine QCT Quercetin Iso Isoquercetin ERD Eriodictyol PACs Proanthocyanidins EGCG ()-Epigallocatechin-3-gallate DHM Dihydromyricetin SI Soybean Isoflavones CAL Calycosin IC II Icariside II SY Safflower Yellow CY Carthamin Yellow AhR Aryl hydrocarbon receptor RTKs Receptor tyrosine kinases GPCRs G protein-coupled receptors References 1 AbdiS

10.5194/bg-11-6427-2014 40 RitzC.SpiessA

Symptoms of Pernicious Anaemia Pernicious Anaemia is a more insidious condition that can produce symptoms gradually over time and get worse without treatment

A growing number of recent studies have demonstrated that iron-dependent programmed cell death, known as ferroptosis, contributes to AD-mediated nerve cell death

These results indicate that decreases in the level of GSH are related to cardiac abnormalities in patients with CVD [166]

10.1016/j.cell.2005.04.011 61 MishaninaT