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In DKD, a vicious circle of insufficient oxygen supply, increased oxygen consumption and abnormalities in oxygen utilization is created

Furthermore, this study also confirmed that liproxstatin-2, a new ferroptosis inhibitor, possessed a prophylactic and therapeutic benefit in alleviating LN patient serum-induced renal tubular epithelial cell ferroptosis[158]

Insulin resistance in SM is the primary defect of T2DM that facilitates the progression of fatty liver disease, deposition of fat in the liver (Figure 1) (110)