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Through comparative analysis of three geographically diverse gut metabolomic datasets (four case-control comparison) encompassing IBD cohorts and non-IBD controls (including patients with varying disease activity states), we identified significant pathway enrichment in aromatic amino acid metabolism, particularly involving tyrosine, phenylalanine, and tryptophan catabolism (Fig

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In addition to their involvement in the stress response, GCs (cortisol, cortisone, and corticosterone) have several essential biological functions