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The pretraining comprised of four sessions on three successive days adopting an accelerating protocol that began at 5 rpm and increased to 20 rpm in 5 min

By preserving mitochondrial function, natural compounds help maintain optimal neuronal energy supply and reduce cellular stress by balancing the activities of LDH (Lactate dehydrogenase) and SDH (Succinate dehydrogenase) enzymes that are involved in cellular metabolism and are often used as markers in various diagnostic tests and research studies to assess tissue damage (Grnewald et al

Similarly, pramipexole, marketed as Mirapex, is also taken orally

The aggregation of such fibrils disrupts cellular function and contributes to neuronal death through several phenomena (38, 39)

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