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Shi S, Lei S, Tang C, Wang K, Xia Z (2019) Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway

Nature 627, 149156

-----THIS INFORMATION IS NOT A SUBSTITUTE FOR, NOR DOES IT REPLACE, PERSONALIZED MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT

Typically, studies tend to be conducted In Vitro first, so within a lab or test tube environment, before moving on to In Vivo when it is deemed safe enough to do so

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Numerous studies highlight its importance in controlling MDSC differentiation into the tumor-suppressive M1 subtype, facilitated by glycolytic reprogramming dependent on the mTOR/HIF-1 pathway [77]