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NUDT15 is involved in the conversion of 6-TGTP and deoxy-TGTP metabolites to TGMP and deoxy-TGMP (Fig

The mechanism of action here seems to be mitochondrial damage and lack of ATP kidney cells use a lot of ATP

Monostori P, Wittmann G, Karg E, Tri S

J Neuropathol Exp Neurol 70(3):167176 Takahashi S (2021) Neuroprotective function of high glycolytic activity in astrocytes: common roles in stroke and neurodegenerative diseases

Glucagon-like peptide-1 receptor (GLP-1 receptor) agonists), such as liraglutide and semaglutide (111), mimic the action of endogenous GLP-1 to increase insulin secretion, suppress glucagon secretion, delay gastric emptying, and promote weight loss

Protocol Compliance: Consistent daily dosing throughout the treatment period produces better results than sporadic use