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also known as leucovorin), a tetrahydrofolic acid derivative, is used in the clinical management of rare inborn errors that affect folate transport or metabolism (reviewed in 182)

however, under pathological conditions, such as insulin resistance and MASLD, dysregulated SREBP2 activity can promote excessive cholesterol synthesis and accumulation [54]

A 2022 trial (N = 60) on photoaging management showed that a 4-week regimen combining oral 70 mg curcumin with topical 0.02% curcumin cream significantly improved skin firmness (+11.2% vs

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