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Vitetta, L., Zhou, J., Manuel, R., Dal Forno, S., Hall, S., & Rutolo, D

It is also worth noting that a large cluster of long heparan polymers on the cell surface could be associated with multiple dimeric c-MET/HGF complexes and in principle induce the higher-order oligomerization of c-METs, and potentially lead to the formation of even larger biomolecular condensates on the cell membrane

Published clinical evidence includes a Phase 1b multiple-ascending-dose trial reported by Enebo and colleagues (Lancet, 2021) and a Phase 2 trial in type 2 diabetes reported by Frias and colleagues (Lancet, 2023), both studying cagrilintide together with semaglutide

Tivantinib (ARQ 197) is a staurosporine derivative and it represents the first non-ATP-competitive c-Met inhibitor that binds to the dephosphorylated c-Met kinase in vitro

Non-erythropoietic: By design it does not stimulate erythropoiesis, avoiding the hematocrit/thrombotic risks associated with EPO

No correction is made for differences in the bioavailability of crystalline B12 from supplements or fortified foods compared with B12 from food because the absorption differences between these two B12 sources are assumed to be small