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Erastin and other molecules (e.g., salazosulfapyridine, sorafenib) can induce ferroptosis by inhibiting system x and reducing GSH production (13, 30)

Notably, the level of glutamate is relatively high compared with that of GABA, caused by various etiologies, including glutamate release by damage-induced depolarization, exaggerated glutamate release through xc(), and attenuated uptake of glutamate through EAATs, or a decrease in GABA release with subsequent increase in glutamate release

O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy

Severe cases need quick action to boost Vitamin B12 levels and ease symptoms

This finding implies that the enhanced release of GSH into the extracellular space may play a role in the upregulation of GPX3 activity within the TME

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