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In addition, cotreatment of docetaxel-resistant NSCLC with docetaxel plus R162 inhibited cancer cell growth and metastasis both in vitro and in xenograft mouse models, again suggesting that combination therapy with anticancer drugs plus a GLUD1 inhibitor is an effective cancer treatment 23

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This synthetic peptide has become one of the most widely studied compounds in peptide biology due to ongoing research into its interactions with cellular signaling pathways, tissue biology, and gastrointestinal physiology

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