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Aquaporin-4 autoantibodies from neuromyelitis optica spectrum disorder patients induce complement-independent immunopathologies in mice

Oligodendrocytes and Myelin Dysfunction : Degeneration of oligodendrocytes disrupts myelin sheath integrity, leading to impaired axonal action potential conduction and neural integrity

All mice that were subjected to an HFD had a higher fat mass compared to the LD control group at the start of the study

Potential Hormonal Effects: Animal studies suggest possible indirect effects on growth factors or hormone regulation, but human relevance is unclear

doi: 10.1056/NEJMoa1300874 101 AdesLGuerciARaffouxESanzMChevallierPLapusanSet al