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In another study, significant improvements were observed in the ABC scale score of 36-week sulforaphane supplementation in children with ASD compared to the placebo group [121]

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Subsequent examination after eight days of co-culture revealed that intestinal organoids derived from the co-culture of ISCs and old Paneth cells exhibited aging characteristics compared to those from the co-culture of ISCs and young Paneth cells, evidenced by a notable reduction in intestinal organoids and organoid bud formations (Fig