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7.2.1 Non-monotonic dose-response relationships 7.2.1.1 Mechanistic understanding of NMDR effects Many EEDs exhibit non-monotonic dose-response curves where low-dose exposure produces greater biological effects than high-dose exposure (139)

doi: 10.3389/fimmu.2024.1391355

[141] [142] [143] As of 2024 [144] federal Medicare Part D does not cover weight-loss drugs, and only a few federally-funded, state-administered Medicaid plans cover drugs for obesity

Novel perspectives on therapeutic modulation of the gut microbiota

however, smoking cessation usually leads to weight gain, often substantial [18, 19], and could therefore differentially affect body weight if participants decided to stop smoking during the trial [19,20,21]