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Considering an estimated average blood volume of approximately 7%8% of body weight in mice ( in vitro IC50 of 613 M for hepatocytes, taking into account the rapid distribution and metabolism occurring in vivo

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For instance, while quercetin has been reported to activate both enzymes, curcumin has shown potential as an activator of SIRT1, promoting its deacetylase activity and contributing to anti-inflammatory effects 178

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When an equimolar concentration of Cu(II) was added to the equimolar mixture of normal 2M and HSA, almost all copper was eluted in a single peak corresponding to CuHSA, demonstrating that 2M cannot compete for Cu(II) ions with HSA even at equimolar concentration (Fig