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Strategies aimed at reducing high glucose levels by employing sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been shown to significantly lessen the onset of cellular senescence, potentially attributed to the synthesis of -hydroxybutyrate ( Telomere shortening is a widely recognized occurrence in both type 1 and type 2 diabetes, and this process may be hastened by factors such as inflammation, hyperglycemia, glycation end products, and persistent oxidative stress (Sutanto et al., 2019

Hypoxia promotes atrial tachyarrhythmias via opening of ATP-sensitive potassium channels

The notable feature of resulting metal complexes of certain flavonoids is that their scavenging potencies toward superoxide are significantly higher than those of the parent flavonoids (Table 3)

In preclinical work it up- and down-regulates a large number of genes tied to matrix production, remodeling, and antioxidant defense, and it ferries copper a cofactor for lysyl oxidase and superoxide dismutase into tissue

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