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The 4 stages of B12 deficiency are as follows: Stage 1: Low levels of vitamin B12 on blood test, but no symptoms

The calorically restricted low-fat nutrient-dense diet in Biosphere 2 significantly lowers blood glucose, total leukocyte count, cholesterol, and blood pressure in humans

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Ethical approval for the use of samples obtained from PLWH treated with IMC-M113V was obtained through the IMC-M113V-103 study (EudraCT 2021-002008-11, 29 Oct 2021), which was approved by the relevant ethics bodies at each participating site as indicated in the Study design and participants section