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Macrophages exposed to choline deficiency or ChoK inhibitors (MN58b or RMS932A) exhibit poor PC and sphingomyelin mitochondrial membrane composition, leading to defective mitochondrial ATP synthesis that boosts AMPK activation and mitophagy ( Figure 3 )

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These signals attach to TLR4 and other TLRs on Kupffer cells and trigger the release of proinflammatory cytokines, such as TNF, chemokines, and reactive oxygen and nitrogen species (140)

Molecular basis of thermosensing: A two-component signal transduction thermometer in Bacillus subtilis

Clinicians can use plasma concentrations and urinary excretion of TRP and its metabolites to assess disease progression and risk