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3.2 Destruction of periodontal soft tissues The integrity and function of PDLFs, essential for softtissue homeostasis, are compromised by ferroptosis through a twofold assault on collagen: synthesis is reduced because PDLF viability and activity are impaired, while degradation is accelerated by ferroptosisassociated ROS and proinflammatory mediators (50)

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Although current research in this field is limited, these findings collectively suggest that targeted induction of microbial ferroptosis could attenuate ALD-driving pathobionts, thereby providing a novel therapeutic perspective for ALD management