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Studies have demonstrated that the polarization of macrophages is controlled by multiple metabolic pathways, such as glycolysis, the pentose phosphate pathway, fatty acid oxidation, sphingolipid metabolism, the tricarboxylic acid cycle, and arginine metabolism

Unlike traditional anti-inflammatories that only suppress symptoms, these supplements for swelling actively promote healing by targeting specific biological pathways

doi: 10.3389/fmicb.2025.1685962 Received 28 August 2025 Accepted 27 October 2025 Published 12 November 2025 Volume 16 - 2025 Edited by Vikash Kumar, Central Inland Fisheries Research Institute (ICAR), India Reviewed by Sijie Wang, Affiliated Hospital of Guangdong Medical College Hospital, China Xuchang Zhou, The First Affiliated Hospital of Xiamen University, China Updates Copyright 2025 Wang, Xu, Zha and Wu

During aging, neutrophils display an extended lifespan and abnormal phenotypic features such as hypersegmentation in secondary lymphoid organs and bone marrow

These gaps highlight the need for future research to move beyond descriptive mechanisms toward systematic dissection of pathway crosstalk, cell type-specific functions, and clinical validation

For instance, even as an Integrative and Functional Pediatrician, I would never approve certain food-based detoxes for a picky-eating child who is already having trouble maintaining or gaining weight