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the prevalence of truncating mutations at this locus, combined with the rarity of synonymous mutations, strongly indicates that RNF43 mutations have been positively selected during the evolution of EC and CRC (Figure 4) (111)

Sequence determinants of intracellular phase separation by complex coacervation of a disordered protein

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The peptide upregulates MMP-2 expression in dermal fibroblasts by 85%, facilitating breakdown of damaged collagen and enabling cellular migration through dense matrix environments, while simultaneously enhancing production of tissue inhibitors of metalloproteinases (TIMPs) to prevent excessive degradation

In vitro, treatment with 20 M ginsenoside Rf inhibited EESC growth

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