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Additionally, FP regulates intestinal epithelial NLRP6 inflammasome activity, promotes -defensin-2/3 secretion, and competitively inhibits colonization by pro-inflammatory microorganisms such as Candida albicans and Escherichia coli ( 3.1.2 Inhibit innate immune overactivation via multiple signaling pathways Beyond barrier repair, butyrate is a core anti-inflammatory mediator by regulating innate immunity ( in vitro culture system of lamina propria mononuclear cells (LPMC) or peripheral blood mononuclear cells (PBMC) derived from CD patients, butyrate acts as a specific inhibitor of class I histone deacetylases (HDACI) and exhibits high responsiveness