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Healthy endothelium has anticoagulant properties that prevent the adhesion of leukocytes and platelets to the vessel walls, contributing to resistance to thrombus formation, and regulating inflammation, and vascular smooth muscle cell proliferation

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Focal, multifocal, and subcapsular necrosis is occasionally seen in untreated rodents and may be a terminal event potentially due to hypoxic change secondary to impaired blood flow

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Colloidal silver products have not undergone safety studies and are not recommended by the FDA