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In addition to movement disorder, different non-motor symptoms such as dementia, psychosis and depression are observed in patients, which increase in late stages of disease

NAD+ (Nicotinamide Adenine Dinucleotide) A coenzyme present in every cell, central to energy metabolism and DNA repair

Type 1 cytokines Cytokines typically produced by T helper 1 cells, including IL-2, interferon- and IL-12

Concurrently, this ROS burst activates the NF-B pathway, perpetuating pro-inflammatory cytokine secretion (TNF-, IL-1, IL-6) and establishing a vicious cycle of chronic inflammation