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The rationale is further supported by several studies that demonstrated that the human gut microbiome is a major determinant of plasma metabolome, potentially playing a more dominant role than genetics

doi: 10.1210/js.2019-00078 80 TamNNGaoYLeungYKHoSM

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Besides, T-lymphocyte distributions of type 1/type 2 are observed to be altered by intense exercise training [113]

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