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Frank DG, Yu-Fen L, Louis D, Kiros B, Edward A, Rob M, et al

A study assessing the effects of C3a on expression of Gfap , Nes , C3ar1 , C3 , Ngf , Tnf and Il1b in naive astrocytes, astrocytes challenged with ischemia and astrocytes exposed to lipopolysaccharide showed that C3a downregulated the expression of Gfap , C3 and Nes in astrocytes after ischemia, and increased the expression of Tnf and Il1b in naive astrocytes and the expression of Nes in astrocytes exposed to lipopolysaccharide, but did not affect the expression of C3ar1 or Ngf 463

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Furthermore, shRNA suppression of SOD1 in sALS astrocytes could confer significant motor neuron protection from ALS astrocyte-derived toxicity, demonstrating that not only mSOD1, but also wild-type SOD1 could be involved in the pathogenesis of sALS [34]

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Estrada LD, Chamorro D, Yaez MJ, Gonzalez M, Leal N, von Bernhardi R, Dulcey AE, Marugan J, Ferrer M, Soto C, et al