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Sequential class switching is required for the generation of high affinity IgE antibodies

| DOI: 10.1097/CMR.0000000000000991 We present a case of a 75-year-old male patient who experienced a severe exacerbation of his Kaposi sarcoma lesions, which have remained clinically stable for a year, following treatment with BRAF/mitogen-activated protein kinase inhibitors for his coexisting melanoma

Through ART testing and a functional stool test , we discovered: Elevated levels of sulphur-reducing bacteria Low molybdenum Impaired sulphite oxidase activity We implemented a low-sulphur diet (temporarily removing garlic, eggs, and cruciferous vegetables), added molybdenum and B12 support , and used targeted probiotics to rebalance her gut microbiome