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In the LC3 lipidation pathway, Atg4 cleaves the LC3 precursor to generate LC3-I, which is then covalently linked by Atg7 to Atg3, forming membrane-anchored LC3-II that integrates into the autophagosome membrane, promoting membrane extension and serving as a marker for substrate recognition, thereby facilitating targeted transport (30)

Indirect tests involve oral administration of test substances, followed by measurement of their concentration in blood or urine

Psychopharmacology 108 , 495500 (1992)

Biochim Biophys Acta 438: 358369 Varandani PT, Nafz MA (1976) Insulin degradation

Deficiency of the mitochondrial transporter SLC25A47 minimally impacts hepatic lipid metabolism in fasted and diet-induced obese mice

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