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A crucial step will be to perform a rigous retrospective validation after harmonized preprocessing (including consistent expression units and rigorous batch correction) to ensure the technical reliability of the analysis

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Although they can both regulate cell apoptosis and cell cycle, cisplatin induces a large number of genes related to DNA damage, P53 and apoptosis, while some ruthenium complexes facilitate the expression of oxidative stress and ER stress ( The existing research achievements should be combined with molecular biology and nanomaterials, applying the advantage of existing tools and methods to develop antitumor drugs with better therapeutic effects, based on these complexes

It is important to note that excessive exercise (e.g., overtraining) is widely reported to decrease levels of androgens (143) and AR (144)