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Stinchcombe TE, Socinski MA

Ramacci, A

J Neurochem 72 : 20392046 Gambarana C, Ghiglieri O, Masi F, Scheggi S, Tagliamonte A, De Montis MG

Butyrate essentially fuels colon cells and is crucial for the neuroimmunoendocrine system, promoting gut health through its anti-inflammatory properties and strengthening the intestinal barrier [43]

Combined with peripheral dopa decarboxylase inhibitors in fixed-dose formulations, it is converted into dopamine after crossing the bloodbrain barrier, effectively compensating for the dopaminergic deficit in the nigrostriatal pathway and significantly improving core motor symptoms such as bradykinesia, rigidity, and tremor [100], long-term use is associated with motor complications including wearing-off phenomena, dyskinesias, and "onoff" fluctuations, as well as peripheral dopaminergic adverse effects such as nausea, vomiting, and hypotension [101, 102]

Sade cardaca: estudos demonstram ao cardioprotetora em pacientes com angina e insuficincia cardaca