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The first model is a two-layer U-shaped A 40 model (PDB ID: 2LMN), 18 while we choose a recently resolved two-layer S-shape fibril model (PDB ID:2NAO) for A 42

J Exp Med (1999) 190:91521

F., Radic, S., Ramirez, J., Riveras, N., Ruiz, G., Salazar, O., Salgado, I., Seguel, O., Seplveda, M., Sierra, C., Tapia, Y., Tapia, F., Toledo, B., Torrico, J

Both conditions can disrupt ciliary function and mucosal barrier integrity, affecting both tolerability and potentially drug absorption