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Carnitine also plays a role in metabolic regulation, detoxification, and cell membrane stabilization.[ref] This article covers: Mitochondrial energy production from long-chain fatty acids How carnitine is synthesized, including genes involved Effect on weight, mental health, immune response, and bone health Genetic changes and inborn errors of metabolism Lifehacks and solutions for optimizing carnitine levels Carnitine in Mitochondrial Energy Production: The Carnitine Shuttle Carnitine plays a specific role in mitochondrial energy production

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Valproic acid is contraindicated in patients known to have mitochondrial disorders caused by POLG mutations and children under two years of age who are clinically suspected of having a mitochondrial disorder [seeContraindications (4)]

Genetically predicted higher l-carnitine was associated with lower HDL-cholesterol in men (effect size 0.04, 95% CI 0.06 to 0.02), and not in women (0.004, 95% CI 0.05 to 0.06, p value=0.88)