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Despite increased expression of complex I and IV proteins with B12 supplementation and previously observed increased complex I and IV OCR in B12-supplemented, aged male mice [26], we did not observe an improvement in mitochondrial complex activity (i.e., oxygen consumption rate) in the aged female mice

In that previous study (which enrolled 377 T2DM and 4741 nondiabetic controls), the prevalence of insomnia in T2DM patients was significantly higher than in nondiabetic controls, in which the prevalence of insomnia was only 12.2% [2]

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