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Current research has found high concentration supplementation, at 180 mcg/day, results in improved clinical results compared to lower-dose supplementation.*

Further, pre-treatment with selenite significantly prevented the radiation-induced mutation of the hprt locus in AA8 cells

The increased flux of acetyl-CoA will then build up the levels of Krebs intermediates including fumarate and succinate (also inhibitors of prolyl hydroxylase), especially if the biotin-dependent pyruvate carboxylase cannot sustain the production of oxaloacetate, the most limiting substrate of the cycle

Both have their place in the right context, and sometimes the best protocol draws on both

This pathway is linked with various ailments including respiratory diseases, inflammatory diseases, auto immune diseases, cancer and diabetes

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