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These agents act only before exposure to noxious substances, lacking therapeutic potential when administered after injury

doi: 10.3389/fneur.2020.00088 Received 19 September 2019 Accepted 24 January 2020 Published 14 February 2020 Volume 11 - 2020 Edited by Pamela Ann McCombe, University of Queensland, Australia Reviewed by Ester Moral, Hospital of Sant Joan Desp Moiss Broggi, Spain

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Both the concentrations and activity of PP2A are significantly reduced in the AD brain (46, 47)

Johnson MP, Kelly G, Chamberlain M (2001) Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists