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10.1073/pnas.1017496108 Proc

CRIP1 fosters MDSC trafficking and resets tumour microenvironment via facilitating NF-B/p65 nuclear translocation in pancreatic ductal adenocarcinoma

Opening at 2 mg weekly rather than 4 mg markedly softens early GI effects, and any higher weekly dose simply calls for more than one vial or a split across two sites

If the Cys to which HNE is bonded is located in a more hydrophobic region of the protein, the significant dipole moment of the aldehyde functionality of HNE will be a driving force to move that Cys closer to the surface of the protein, thereby exposing hydrophobic regions of the protein to the aqueous phase

A., Stoffel, M., Alva, H

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