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The absence of evidence of harm is not evidence of absence of harm it is the direct consequence of the compound never having been studied for human use

Voineagu I, Wang X, Johnston P, Lowe JK, Tian Y, Horvath S, et al

Trends Pharmacol Sci 24(5):253259 Singh M (2024) "Review of thyroid Storm diagnosis and treatment." ScienceOpen Posters

doi: 10.3390/molecules27217223 172

78 Genotyping for the presence of Thr92Ala polymorphism in patients treated for hypothyroidism revealed that Ala/Ala homozygotes had worse quality of life scores while taking LT4

Compared to acute patients, we noted 495 metabolites were significantly reduced but 167 metabolites were elevated in the plasma of LC patients ( Figure 2I )