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Mechanism of Action of IGF-1 LR3 IGF-1 LR3 binds to the IGF-1 receptor (IGF1R) , activating intracellular pathways such as: PI3K/Akt/mTOR pathway Drives protein synthesis and muscle growth MAPK pathway Influences cell proliferation and differentiation Key effects include: Stimulating muscle stem cells (satellite cells) Increasing nitrogen retention in muscle tissue Enhancing glucose uptake for energy and glycogen replenishment Promoting connective tissue healing 6

Borosilicate glass vials are the gold standard for peptide storage

(J Am Soc Nephrol 20: 1754-1764, 2009) can be adapted to the CRISRP-Cas system of the present invention and a cumulative dose of 12- 20 mg/kg to a human can be used for delivery to the proximal tubule cells of the kidneys

This ingredient is intended for use in extemporaneous compounding only

Ausubel, et al

VEGF Signaling, ACTN4