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Medically reviewed by Alan Lucks | MD , Alan Lucks MDPC Private Practice - New York on December 2nd, 2025

GIP receptor activation in the brain and adipose tissue influences energy partitioning and fat metabolism through mechanisms distinct from both GLP-1 and amylin

Zepbound is the first and only approved treatment activating two incretin hormone receptors, GIP and GLP-1, to tackle an underlying cause of excess weight, according to Lillys announcement