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In H 2 O 2 -induced oxidative stress models, curcumin has been shown to promote autophagy, potentially via inhibition of the AMPK/mTOR pathway in granulosa cells (Xu G

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Allergic reactions including angioneurotic edema have also been reported in postmarketing experience

Role of the intestinal tract in the elimination of uric acid

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Specifically, treatment with IGF-1 prevented etoposide-induced podocyte apoptosis, whereas these protective actions were blocked by inhibition of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, highlighting the critical role of this signaling pathway as a key downstream mechanism.61 Moreover, in vitro studies have shown that IGF-1 signaling is crucial for mesenchymal stem cell-mediated recovery of renal function and tubular cell structure following cisplatin-induced damage.62 Notably, mesenchymal stem cells over-expressing IGF-1 significantly improved outcomes in a rat model of acute kidney injury, enhancing renal function and preventing apoptosis, oxidative stress and inflammation.63 Based on the studies mentioned above, treatment with IGF-1 appears to be beneficial for renal function