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Correlations between participants clinical and glycaemic characteristics and performance on the vMWMT, including both the hidden platform phase (time to first move, time to platform and path length) and the probe phase (time spent in the correct quadrant), were evaluated with Pearson or Spearman correlation coefficients, depending upon the normality of variable distributions

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In the STEP-1 trial of 1,961 adults (Wilding and colleagues, Once-Weekly Semaglutide in Adults with Overweight or Obesity, New England Journal of Medicine, 2021), participants on semaglutide 2.4 mg lost an average of 14.9 percent of their body weight at 68 weeks, compared to 2.4 percent on placebo