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The answer is a resounding yes and a firm no

& Birkov, A

On the other hand, cysteine needs to be imported from plasma into the brain in order to synthetize glutathione (GSH), and this import is mediated by system X C (Figure 1)

This work reveals that metastasizing melanoma cells in lymphatic vessels experience less oxidative stress than cells in the blood because they are protected from ferroptosis, and thus are more efficient to form metastases