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Most mass-market B12 supplements use cyanocobalamin, which is cheaper to manufacture but must be converted in the liver before it becomes metabolically active

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One study aiming to achieve this is the DecodeME study that launched September 2022 (586)

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Understanding the Standard 1000 mcg (1 mL) Dosage The usual dose for vitamin B12 shots is 1000 mcg, or 1 mL