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Participants were recruited and randomly assigned to a treatment group prior to undergoing surgery, which is needed to determine whether a patient has low-grade or high-grade disease

In a separate calibration curve, a constant amount of the internal standard [ 13 C 15 N 2 ]8-oxo-dG (1 fmol/L) was mixed with different amounts of 8-oxo-dG (10400 fmol/L)